Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands.

نویسندگان

  • William C Florence
  • Chengfeng Xia
  • Laura E Gordy
  • Wenlan Chen
  • Yalong Zhang
  • James Scott-Browne
  • Yuki Kinjo
  • Karl O A Yu
  • Santosh Keshipeddy
  • Daniel G Pellicci
  • Onisha Patel
  • Lars Kjer-Nielsen
  • James McCluskey
  • Dale I Godfrey
  • Jamie Rossjohn
  • Stewart K Richardson
  • Steven A Porcelli
  • Amy R Howell
  • Kyoko Hayakawa
  • Laurent Gapin
  • Dirk M Zajonc
  • Peng George Wang
  • Sebastian Joyce
چکیده

The semi-invariant natural killer (NK) T-cell receptor (NKTcr) recognises structurally diverse glycolipid antigens presented by the monomorphic CD1d molecule. While the alpha-chain of the NKTcr is invariant, the beta-chain is more diverse, but how this diversity enables the NKTcr to recognise diverse antigens, such as an alpha-linked monosaccharide (alpha-galactosylceramide and alpha-galactosyldiacylglycerol) and the beta-linked trisaccharide (isoglobotriaosylceramide), is unclear. We demonstrate here that NKTcrs, which varied in their beta-chain usage, recognised diverse glycolipid antigens with a similar binding mode on CD1d. Nevertheless, the NKTcrs recognised distinct epitopic sites within these antigens, including alpha-galactosylceramide, the structurally similar alpha-galactosyldiacylglycerol and the very distinct isoglobotriaosylceramide. We also show that the relative roles of the CDR loops within the NKTcr beta-chain varied as a function of the antigen. Thus, while NKTcrs characteristically use a conserved docking mode, the NKTcr beta-chain allows these cells to recognise unique aspects of structurally diverse CD1d-restricted ligands.

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عنوان ژورنال:
  • The EMBO journal

دوره 28 22  شماره 

صفحات  -

تاریخ انتشار 2009